Pterostilbene could very well be the most significant health discovery for avoiding or at least minimizing, many degenerative diseases and adding years of healthy living to your life. Pterostilbene is a photochemical found in small berries, most abundant in blue berries. It is a structural analog of resveratrol, and it shares many chemical, physiological and pharmacological health benefits of resveratrol such as; anti-aging, anti-diabetic, anti-inflammatory, anti-obesity, antioxidant, cognitive enhancement, and hypolipidemic activity (reduces excessive fats in the body and promotes healthy cholesterol)*. Yet it is far more powerful.

Laboratory and clinical studies confirm that pterostilbene is more biologically active in the body than resveratrol. Pterostilbene stays in the blood up to 7 times longer. It has a much higher affinity for lipids and as a result has a higher potential for cellular uptake. But the greatest contribution pterostilbene offers for the prospects of a healthful longevity is its effects on gene sequencing by mimicking caloric restriction.

Absolutely the Most Significant Step You Can Do To Improve Your Health and Change Your Life

The tremendous cost of obesity is well documented. Not just in terms of dollar cost from excessive medical bills and lost time at work, but the emotional and mental drain it causes. But few realize that caloric restriction actually turns on genes directly related to a longer life and genes that protect the body from many age related degenerative diseases⁴*. This includes genes that reduce the activity of certain cancer-promoting agents, genes that induce the programmed death of cancer cells, and genes that confer neuroprotection⁵.*

It’s truly remarkable how closely pterostilbene can mimic the beneficial effects of calorie restriction on a molecular level. Calorie restriction directly suppresses cancer-causing genes while up-regulating genes that suppress cancer development. In numerous studies pterostilbene modulates exactly the same genes, upregulating those that stimulate the programmed cell death known as apoptosis, and down-regulating those that allow cancer cells to invade and metastasize⁶.*

Calorie restriction changes expression of genes throughout the metabolic process. It increases activity of powerful fat-sensing complexes that lower blood lipids and sugar levels. Pterostilbene naturally activates these same fat-sensing complexes and was found to favorably affect lipid profiles in hamsters with elevated cholesterol⁷.*

Calorie restriction dramatically reduces production of inflammatory mediators linked to age-related conditions such as atherosclerosis, chronic inflammatory diseases, and even cognitive decline*. At the level of gene expression, pterostilbene exerts virtually identical effects, suppressing those same genes in studies of inflammation-related conditions. And like calorie restriction, pterostilbene up-regulates specific brain proteins associated with improved memory⁸.*

Pterostilbene Synergistically Compliments the
Health Benefits of Resveratol

Resveratrol activates genes near the beginning of the molecular cascade precipitated by caloric restriction. These in turn activate a broad array of disease-preventing genes. In essence, resveratrol’s beneficial genetic action takes place “upstream.”

Pterostilbene directly activates genes “downstream” from the sites of resveratrol’s action. This complements resveratrol’s ability to help prevent cancer and diabetes, and supports healthy blood lipids*. Acting together, resveratrol and pterostilbene produce potent longevity-promoting effects across the cycle of gene expression through complementary mechanisms*.

  ▲  top of page

Clinical Research     |    Pterostilbene Analytical Test Results